Cheslin Kolbe, Bryan Habana and Schalk Brits, have all been withdrawn from the SA Sevens squad to compete at the Commonwealth Games.
SASCOC have confirmed enforced late changes to the squad to compete at the 201 Games in Glasgow, Scotland.
Kolbe, the Western Province and Stormers speedster, has been withdrawn by Western Province due to a knee injury.
This follows the earlier withdrawals of established Springbok 15-man code players, Habana and Brits, who were not released by their respective French and English leagues.
Warrick Gelant was due to replace Kolbe but was injured at the weekend and will undergo surgery this week. This sees Mark Richards, a member of the gold-medalling SA sevens team at the World Games in Colombia last year, coming in as a late replacement.
The sevens side is part of the more than 150-strong Team South Africa that flew out of OR Tambo International Airport en route to the Commonwealth Games.
SA Sevens squad: Chris Dry, Kwagga Smith, Frankie Horne, Warren Whiteley, Cornal Hendricks, Kyle Brown, Branco du Preez, Mark Richards, Justin Geduld, Cecil Afrika, Werner Kok and Seabelo Senatla.