Elton Jantjies will start at fly-half for the Lions when they face the Sharks in Durban on Saturday.
With Jantjies returning to action, after recovering from a shoulder injury, Lions boss Johan Ackermann has reshuffled his back-line with Marnitz Boshoff shifting to full-back.
Chrysander Botha, who was in the number 15 jersey in last weekend's loss to the Bulls, starts at left wing while Ruan Combrinck moves across to right wing in place of Deon van Rensburg, who takes over from JW Jonker at outside centre.
In the forwards, Ackermann has opted largely for consistency, making just one change in the front row.
Willie Wepener comes into the starting line-up at hooker, as Robbie Coetzee shifts to the bench.
Amongst the replacements, Corne Fourie provides cover at prop will look to make his Super Rugby debut.
Lions: 15 Marnitz Boshoff, 14 Ruan Combrinck , 13 Deon van Rensburg , 12 Stefan Watermeyer, 11 Chrysander Botha, 10 Elton Jantjies, 9 Faf de Klerk, 8 Warren Whiteley (c), 7 Warwick Tecklenburg, 6 Jaco Kriel, 5 Franco van der Merwe, 4 Franco Mostert, 3 Julian Redelinghuys, 2 Willie Wepener, 1 Schalk van der Merwe.
Replacements: 16 Robbie Coetzee, 17 Corne Fourie, 18 Ruan Dreyer, 19 MB Lusaseni , 20 . Willie Britz, 21 Ross Cronje, 22 JW Jonker, 23 Coenie van Wyk.
Date: Saturday, March 8
Kick-off: 19:10 local (17:10 GMT)
Venue: Kings Park Stadium, Durban
Referee: Jaco Peyper (South Africa)
Assistant referees: Stuart Berry (South Africa), Cobus Wessels (South Africa)
Television match official: Shaun Veldsman (South Africa)