France's replacement centre Florian Fritz has been ruled out of his country's final Six Nations match with Scotland in Paris on Saturday.
The 29-year-old Toulouse star failed to recover from a left foot infection and has been replaced on the bench by the uncapped Gael Fickou.
"Florian Fritz will not be fit for Saturday," said a French team spokesman.
"He has a blister that has infected his left foot. He has been replaced by Gael Fickou."
Fritz, who started the 13-13 draw with Ireland last Saturday, had been unable to train since last Monday.
Fickou, 18, had been called up for the pre-Six Nations preparations but has played for the U20 side during the tournament.
France need to beat Scotland to give themselvees a chance of avoiding their first wooden spoon since 1999 and their first in this year's Six Nations.
France (revised): 15 Yoann Huget, 14 Vincent Clerc, 13 Mathieu Bastareaud, 12 Wesley Fofana, 11 Maxime Médard, 10 Frederic Michalak, 9 Morgan Parra, 8 Louis Picamoles, 7 Thierry Dusautoir, 6 Antonie Claassen, 5 Yoann Maestri, 4 Sebastien Vahaamahina, 3 Nicolas Mas, 2 Benjamin Kayser, 1 Thomas Domingo.
Replacements: 16 Guilhem Guirado, 17 Vincent Debaty, 18 Luc Ducalcon, 19 Christophe Samson, 20 Yannick Nyanga, 21 Maxime Machenaud, 22 François Trinh-Duc, 23 Gael Fickou.