Wales back-rower Ryan Jones will miss Saturday's opening end-of-year Test with Argentina at the Millennium Stadium due to a shoulder injury.
The Ospreys stalwart was forced to fly back to Wales from the national team's training camp in Poland last week for scans on his troublesome shoulder.
After receiving the scans Wales' medical staff decided Jones needs further rest to fully recover from the injury.
The 31-year-old is, however, expected to be available for selection when Wales face Samoa in Cardiff on November 16.
Jones is the latest casualty in Wales camp ahead of their upcoming international programme which also includes Tests against New Zealand and Australia.
Newport Gwent Dragons flanker Dan Lydiate will not play for Wales again this year after breaking and dislocating his ankle on regional duty while veteran tighthead prop Adam Jones will also miss the upcoming Tests due to a knee injury.
Jones and Lydiate's absence could open the door for Scarlets blindside flanker Aaron Shingler to cement his place in the run-on side.
Caretaker coach Rob Howley could, however, move skipper Sam Warburton into the number six position and include Justin Tipuric on the openside.
Wales will name their team to face Argentina on Tuesday.