The Waratahs will face the Stormers in Cape Town this Saturday without the services of try-scoring superstar full-back Israel Folau.
Folau was rated 50-50 to take part in Saturday's game at Newlands after a blow to the throat two weeks ago in the Waratahs' win over the Rebels.
The Australian international consequently missed last weekend's loss to the Sharks in Durban, but there had been hope that he would play some part against the struggling Stormers.
Now that will not be the case, with Kurtley Beale reverting to full-back and swapping with Jono Lance, who moves to inside centre.
Following a tackle from Fran Steyn, Beale has recovered from a minor case of whiplash to wear number 15 for the first time in 2014.
With Rob Horne suspended, Alofa Alofa returns to the team on the right wing, partnering Peter Betham who remains on the left.
With Wycliff Palu ruled out with an ankle injury suffered in the loss to the Sharks in Durban, Cheika has been forced to reshuffle his back row.
Captain Dave Dennis has been moved to number eight and Jacques Potgieter finds himself in his favourite spot in the back row.
With Potgieter out of the tight five, man mountain Will Skelton gets his chance and will start at lock alongside Kane Douglas.
Coach Cheika has stuck solid with the front row of Benn Robinson at loosehead, Sekope Kepu at tighthead and Tatafu Polota Nau at hooker.
The halves are untouched with Nick Phipps and Bernard Foley in the playmaker roles.
Last year the Waratahs beat the Stormers 21-15 at home in Sydney.
Waratahs: 15 Kurtley Beale, 14 Alofa Alofa, 13 Adam Ashley-Cooper, 12 Jono Lance, 11 Peter Betham, 10 Bernard Foley, 9 Nick Phipps, 8 Dave Dennis (c), 7 Michael Hooper, 6 Jacques Potgeiter, 5 Kane Douglas, 4 Will Skelton, 3 Sepoke Kepu, 2 Tatafu Polota-Nau, 1 Benn Robinson
Date: Saturday, April 5
Venue: Newlands Stadium, Cape Town
Kick-off: 19:10 local (18:10 BST, 17:10 GMT)
Referee: Glen Jackson (New Zealand)
Assistant Referees: Mike Fraser (New Zealand), Quinton Immelman (South Africa)
TMO: Shaun Veldsman (South Africa)