Sale Sharks lock Richie Gray has pulled out of Friday's Aviva Premiership clash against Worcester Warriors at Sixways.
The Scotland star has suffered a reaction to his ankle injury in a fitness test at the team hotel.
His place will be taken by Kearnan Myall with Mark Easter coming in to take Myall's place on the bench.
Sale (revised): 15 Nick Macleod, 14 Tom Brady, 13 Johnny Leota, 12 Sam Tuitupou, 11 Mark Cueto, 10 Danny Cipriani, 9 Cillian Willis, 8 Andy Powell, 7 David Seymour (capt), 6 Richie Vernon, 5 Fraser McKenzie, 4 Kearnan Myall, 3 Tony Buckley, 2 Tommy Taylor, 1 Ross Harrison.
Replacements: 16 Joe Ward, 17 Eifion Lewis-Roberts, 18 Vadim Cobilas, 19 Mark Easter, 20 James Gaskell, 21 Nathan Fowles, 22 Rob Miller, 23 Will Addison.